Detecting Rare Variant Effects Using Extreme Phenotype Sampling in Sequencing Association Studies
نویسندگان
چکیده
منابع مشابه
Detecting rare variant effects using extreme phenotype sampling in sequencing association studies.
In the increasing number of sequencing studies aimed at identifying rare variants associated with complex traits, the power of the test can be improved by guided sampling procedures. We confirm both analytically and numerically that sampling individuals with extreme phenotypes can enrich the presence of causal rare variants and can therefore lead to an increase in power compared to random sampl...
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Next-generation sequencing technology has made it possible to detect rare genetic variants associated with complex human traits. In recent literature, various methods specifically designed for rare variants are proposed. These tests can be broadly classified into burden and nonburden tests. In this paper, we take advantage of the burden and nonburden tests, and consider the common effect and th...
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ژورنال
عنوان ژورنال: Genetic Epidemiology
سال: 2012
ISSN: 0741-0395
DOI: 10.1002/gepi.21699